The American Society of Mechanical Engineers (ASME)
1+ months

JBEI Postdoctoral Appointee - Enzymatic lignin depolymerization

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This postdoctoral position is a temporary position for up to one year, which may be renewed at Sandia's discretion up to five additional years\. The PhD must have been conferred within five years prior to employment\.

Individuals in postdoctoral positions may bid on regular Sandia positions as internal candidates, and in some cases may be converted to regular career positions during their term if warranted by ongoing operational needs, continuing availability of funds, and satisfactory job performance\.


We are seeking a postdoctoral associate to join our team working on understanding biological lignin degradation and conversion into valuable bioproducts\. The project team is working with scientists at the Joint BioEnergy Institute to investigate how microbes and microbial communities depolymerize lignin to smaller fractions and subsequently metabolize the resulting compounds\.

On any given day, you may be called on to:

+ Focus primarily on studying the enzymes involved in the processes listed above, with a particular focus on developing a system for efficient heterologous expression of lignolytic enzymes in yeast, fungi and plants, understanding the enzymology of lignin degradation and optimizing enzyme mixtures for generation of defined intermediates from lignin\. Enzymes will be characterized on relevant model substrates as well as on lignin streams coming from pretreated biomass and will be studied both in isolation and in combination with other enzymes;

+ Utilize a strong background in molecular biology, biochemistry and enzymology, particularly as they apply to studying enzymes involved in lignin degradation and metabolism;

+ Collaborate closely with other JBEI scientists, so the abilities to work in teams and communicate effectively are critical\.


+ PhD in Biochemistry, Molecular Biology, Biochemical Engineering, Chemistry or other relevant field;

+ Extensive experience in heterologous protein expression in yeast, fungi, and/or plants, protein purification, biophysical characterization and enzymology;

+ Demonstrated track record of publishing in peer\-reviewed scientific literature;


+ Strong interpersonal and communication skills;

+ Ability to work with multi\-disciplinary teams;

+ Previous research experience with lignolytic enzymes, including laccases, peroxidases and enzymes involved in the metabolism of aromatic compounds derived from lignin;

+ Previous research experience in the field of lignin depolymerization and development of assays methods for detecting lignolysis products;

+ Experience engineering enzymes for improved stability and performance;

+ Experience with high\-throughput enzyme assay development and enzyme mixture optimization\.

Department Description:

The Biomass Science and Conversion Technology department is dedicated to developing and advancing innovative technologies for producing the next generation of biofuels\. Our multidisciplinary staff represents a diverse range of backgrounds and skill sets: molecular biology, chemistry, chemical and biochemical engineering, biophysics, computational science, and biochemistry\. We partner broadly with other Sandia departments as well as other national laboratories, industry, and universities to develop practical, science\-based solutions to national energy goals\. We also play an essential role in the DOE Joint BioEnergy Institute \(JBEI\), one of three Bioenergy Research Centers in the Nation advancing the next generation of biofuel technologies\.

About Sandia:

Sandia National Laboratories is the nations premier science and engineering lab for national security and technology innovation, with teams of specialists focused on cutting\-edge work in a broad array of areas\. Some of the main reasons we love our jobs:

+ Challenging work withamazingimpact that contributes to security, peace, and freedom worldwide

+ Extraordinary co\-workers

+ Some of the best tools, equipment, and research facilities in the world

+ Career advancement and enrichment opportunities

+ Flexible schedules, generous vacations,strongmedical and other benefits, competitive 401k, learning opportunities, relocation assistance and amenities aimed at creating a solid work/life balance\*

_World\-changing technologies\. Life\-changing careers\._ Learn more about Sandia at: http://www\.sandia\.gov

\*These benefits vary by job classification\.

Security Clearance:

This position does not currently require a Department of Energy \(DOE\)\-granted security clearance\.

Sandia will conduct a pre\-employment drug testing, and a pre\-employment background review that includes personal reference checks, law enforcement record checks, and employment and education verifications\. Further, employees in New Mexico must pass a U\.S\. Air Force background screen for access to the work site\. Substance abuse or illegal drug use, falsification of information, criminal activity, serious misconduct or other indicators of untrustworthiness can cause access to be denied or terminated, rendering the inability to perform the duties assigned and resulting in termination of employment\.

If hired without a clearance, and one subsequently becomes required or you bid on positions that require a DOE\-granted security clearance, a pre\-processing background review that includes personal reference checks, law enforcement record and credit checks, and employment and education verifications may be conducted prior to a required federal background investigation\. Applicants for DOE\-granted security clearances must be U\.S\. citizens and be able to obtain and maintain the appropriate DOE security clearance as required for the position\.

EEO Statement:

Equal opportunity employer/Disability/Vet/GLBT


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JBEI Postdoctoral Appointee - Enzymatic lignin depolymerization

Sandia National Laboratories

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