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Postdoctoral Appointee

Sandia National Laboratories

Livermore, CA
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Job Details

Job ID: 657969
Company: Sandia National Laboratories
Location: Livermore, CA
Job Title:Postdoctoral Appointee


The Post-Doctoral Appointee Program is designed to recruit outstanding Ph.D. applicants to assist a line organization in meeting its mission objectives and to provide a professional technical work environment for the employee. The Ph.D. must have been conferred within one to five years prior to employment. These assignments are for a one-year period, with the option at management?s discretion to serve no more than five additional one-year assignments.

Sandia/California?s Systems Biology Department is seeking a highly motivated virologist/immunologist postdoctoral appointee to join a multidisciplinary team using immunotherapy, computational biology/chemistry, high-throughput screening and gene editing to developing medical countermeasures for infectious disease. The successful postdoctoral candidate will help generate, screen, engineer, and optimize therapeutic antibodies using animal models, molecular biology, immunoassays, and cell-based assays. The indidivual will be a key participant in the projects that involve experimentation in Biosafety level 3 (BSL3) facilities and animal models of infectious disease. The successful postdoctoral candidate will also be responsible for the effective communication of research results through publications and conference presentations.

Other Duties include:

? Discover and characterize monoclonal antibodies in vitro and in vivo

? Antibody engineering

? Develop in vitro and in vivo models to monitor CNS uptake

? Evaluate target antibodies using in vitro biochemical/immunological assays, cell-based viral growth assays, and in vivo models of infectious disease

? Data interpretation, manuscript preparation, publication and presentation


Candidates must have a recent PhD degree in Microbiology, Immunology, Cell and Molecular, Biomedical Sciences or related field. Experience in animal models of disease and basic animal handling is required, to include dose refinement, measurement of host response, pharmacokinetics, pharmacodynamics, and protection against challenge. Incumbent should be able to perform routine tasks involved in a virology laboratory, including knowledge of techniques and basic safety procedures in BSL2 (or higher) environment and proper storage and handling of viruses. Experience with molecular techniques including PCR, primer design, DNA/RNA sample preparation, molecular cloning, Northern blots, Western blots, and immunoassays (flow cytometry, ELISA, immunocytochemistry) is required. The candidate must be a strong individual contributor within a multidisciplinary team comprising engineers, biologists, chemists, and programmers, within the framework of a milestone-driven research project. Strong written and oral communication skills are required. A demonstrated record of high technical achievement (e.g. as evidenced by publication in high-impact scientific journals) and the demonstrated ability to conduct creative, independent research is required.


Knowledge of general immunology, virology and immune evasion by viruses. Experience in assay development, phage display, methods to characterize binding affinity and thermodynamic properties, label-free technologies for measuring biomolecular interactions (SPR or BLI), and high-throughput screening methods is desired. Protein optimization laboratory research experience is desired, particularly in the production and engineering of antibodies and structural based protein design. Familiarity with in vivo methods to measure CNS uptake, including pharmacokinetic techniques (intravenous administration and tissue sampling), brain perfusions, microdialysis, and imaging techniques is desired.

The Systems Biology Department performs biological and bioengineering research with applications in national security, healthcare, and alternative energy. The department is composed of a multidisciplinary team of staff, postdocs, technologists, and students with expertise in microbiology, virology, molecular biology, computational biology, and analytical chemistry. The basic research activities in the department are focused on the identification and characterization of clinical and environmental pathogens, developing a systems-level understanding of host-pathogen interactions, and microbiomes relevant to human health and the environment. Applied research activities are focused on enzyme and microbial engineering for biofuels development, biological detection, and medical diagnostics..

About Sandia:

Sandia National Laboratories is the nation?s premier science and engineering lab for national security and technology innovation, with teams of specialists focused on cutting-edge work in a broad array of areas. Some of the main reasons we love our jobs:

+ Challenging work withamazingimpact that contributes to security, peace, and freedom worldwide
+ Extraordinary co-workers
+ Some of the best tools, equipment, and research facilities in the world
+ Career advancement and enrichment opportunities
+ Flexible schedules, generous vacations,strongmedical and other benefits, competitive 401k, learning opportunities, relocation assistance and amenities aimed at creating a solid work/life balance*

_World-changing technologies. Life-changing careers._ Learn more about Sandia at: http://www.sandia.gov

*These benefits vary by job classification.

Security Clearance:

This position does not currently require a Department of Energy (DOE)-granted security clearance.

Sandia will conduct a pre-employment drug testing, and a pre-employment background review that includes personal reference checks, law enforcement record checks, and employment and education verifications. Further, employees in New Mexico must pass a U.S. Air Force background screen for access to the work site. Substance abuse or illegal drug use, falsification of information, criminal activity, serious misconduct or other indicators of untrustworthiness can cause access to be denied or terminated, rendering the inability to perform the duties assigned and resulting in termination of employment.

If hired without a clearance, and one subsequently becomes required or you bid on positions that require a DOE-granted security clearance, a pre-processing background review that includes personal reference checks, law enforcement record and credit checks, and employment and education verifications may be conducted prior to a required federal background investigation. Applicants for DOE-granted security clearances must be U.S. citizens and be able to obtain and maintain the appropriate DOE security clearance as required for the position.

EEO Statement:

Equal opportunity employer/Disability/Vet/GLBT

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