The American Society of Mechanical Engineers (ASME)
3 days old

Postdoctoral Appointee

Livermore, CA
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  • Job Code
    658639

Job ID: 658639
Company: Sandia National Laboratories
Location: Livermore, CA
Job Title:Postdoctoral Appointee

:

The Post-Doctoral Appointee Program is designed to recruit outstanding Ph.D. applicants to assist a line organization in meeting its mission objectives and to provide a professional technical work environment for the employee. The Ph.D. must have been conferred within one to fiveyears prior to employment. These assignments are for a one-year period, with the option at management?s discretion to serve no more than five additional one-year assignments.

Sandia/California?s Systems Biology Department is seeking a highly motivated immunologist/microbiologist/developmental/molecular biologist or biomedical engineering postdoctoral appointee to join a multidisciplinary team using primary cell gene editing, high-throughput screening and bioinformatics to develop new therapeutic modalities for infectious disease. The successful postdoctoral candidate will help generate, screen, engineer, and optimize cell-based therapies using molecular biology, gene editing (e.g., CRISPR/Cas9 DNA editing, CRISPRi, CRISPRa), cell-based assays, and cell and animal models of bacterial infection. The individual may participate in projects that involve experimentation in Biosafety level 3 (BSL3) facilities and animal (mouse) models of infectious disease. The successful postdoctoral candidate will also be responsible for the effective communication of research results through publications and conference presentations.

Required:



This position requires a recent PhD in biology or a related scientific discipline. Required technical skills and qualifications include standard molecular biology methods, mammalian tissue culture (cell lines and primary cells), and microbiology techniques. Facility with ELISA or other methods of characterizing cell surface protein expression is needed. The candidate should be familiar with next-generation sequencing technologies and their applications, as well as modern genome editing technologies (e.g., CRISPR-Cas9). The candidate must be a strong individual contributor within a multidisciplinary team comprising experimental biologists and bioinformaticians, within the framework of a milestone-driven research project. Strong written and oral communication skills are required. A demonstrated record of high technical achievement (e.g. as evidenced by a strong publication record) and the demonstrated ability to conduct creative, independent research is required.

Desired:

Knowledge of general immunology, microbiology and immune evasion by microbial pathogens, or experience with tissue or organ engineering, especially ex vivo cell based techniques are all a plus. Prior experience in Biosafety level 3 (BSL3) facilities and/or working with animal (mouse) models of infectious disease is desired. Other desired qualifications include familiarity with one or more of the following: experimental design and analysis of high throughput screens, interest in and/or experience with bioinformatics and data analytics, flow cytometry, fluorescence microscopy, single-cell-based quantitative analyses.



The Systems Biology Department performs biological and bioengineering research with applications in national security, healthcare, and alternative energy. The department is composed of a multidisciplinary team of staff, postdocs, technologists, and students with expertise in microbiology, virology, molecular biology, computational biology, and analytical chemistry. The basic research activities in the department are focused on the identification and characterization of clinical and environmental pathogens, developing a systems-level understanding of host-pathogen interactions, and microbiomes relevant to human health and the environment. Applied research activities are focused on enzyme and microbial engineering for biofuels development, biological detection, and medical diagnostics.


About Sandia:


Sandia National Laboratories is the nation?s premier science and engineering lab for national security and technology innovation, with teams of specialists focused on cutting-edge work in a broad array of areas. Some of the main reasons we love our jobs:

+ Challenging work withamazingimpact that contributes to security, peace, and freedom worldwide
+ Extraordinary co-workers
+ Some of the best tools, equipment, and research facilities in the world
+ Career advancement and enrichment opportunities
+ Flexible schedules, generous vacations,strongmedical and other benefits, competitive 401k, learning opportunities, relocation assistance and amenities aimed at creating a solid work/life balance*

_World-changing technologies. Life-changing careers._ Learn more about Sandia at: http://www.sandia.gov

*These benefits vary by job classification.



Security Clearance:


This position does not currently require a Department of Energy (DOE)-granted security clearance.

Sandia will conduct a pre-employment drug testing, and a pre-employment background review that includes personal reference checks, law enforcement record checks, and employment and education verifications. Further, employees in New Mexico must pass a U.S. Air Force background screen for access to the work site. Substance abuse or illegal drug use, falsification of information, criminal activity, serious misconduct or other indicators of untrustworthiness can cause access to be denied or terminated, rendering the inability to perform the duties assigned and resulting in termination of employment.

If hired without a clearance, and one subsequently becomes required or you bid on positions that require a DOE-granted security clearance, a pre-processing background review that includes personal reference checks, law enforcement record and credit checks, and employment and education verifications may be conducted prior to a required federal background investigation. Applicants for DOE-granted security clearances must be U.S. citizens and be able to obtain and maintain the appropriate DOE security clearance as required for the position.

EEO Statement:

Equal opportunity employer/Disability/Vet/GLBT



Categories

  • Mechanical Engineering - Applied Mechanics

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Postdoctoral Appointee

Sandia National Laboratories
Livermore, CA

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Livermore, CA

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